
A peer-reviewed study published in JAMA Health Forum on July 3, 2025 by researchers at Stanford University and Universita Cattolica del Sacro Cuore (Rome) estimated that COVID-19 vaccination averted more than 2.5 million deaths and saved roughly 14.8 million life-years globally between 2020 and 2024 - about one death averted per 5,400 doses. Nearly 90% of the lives saved were among adults aged 60 and over, and most benefit accrued to people vaccinated before infection and during the Omicron wave. The authors described their figures as deliberately conservative, with sensitivity analyses ranging from 1.4 to 4.0 million lives saved.
A peer-reviewed study published in JAMA Health Forum on July 3, 2025 by researchers at Stanford University and Universita Cattolica del Sacro Cuore (Rome) estimated that COVID-19 vaccination averted more than 2.5 million deaths and saved roughly 14.8 million life-years globally between 2020 and 2024 - about one death averted per 5,400 doses. Nearly 90% of the lives saved were among adults aged 60 and over, and most benefit accrued to people vaccinated before infection and during the Omicron wave. The authors described their figures as deliberately conservative, with sensitivity analyses ranging from 1.4 to 4.0 million lives saved.
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A rigorous quantification of large-scale lives saved provides evidence supporting continued investment in immunization systems, reinforcing the investment driver.